The influence of sex steroids on pineal enzymes

dc.contributor.author	Daya, Santylal
dc.date.accessioned	2026-03-04T14:38:16Z
dc.date.issued	1982,2013-03-28
dc.description.abstract	The influence of the gonadal sex steroids namely, estradiol, progesterone and testosterone on the two major enzymes responsible for the synthesis of melatonin in the pineal gland was investigated. These enzymes are Serotonin-N-acetyltransferase (SNAT) and Hydroxyindole-O-methyltransferase (Hl0MT). Testosterone was found to be the only sex steroid capable of influencing SNAT activity whereas all three of the sex steroids were found to influence Hl0MT activity in a biphasic dose-dependent manner. The influence of these sex steroids on radiolabeled serotonin metabolism by pineals in organ culture was also investigated. Ovariectomy, castration and the sex steroids were all found to alter the pattern of the radiolabeled serotonin metabolism by these pineal glands in organ culture.,KMBT_363,Adobe Acrobat 9.53 Paper Capture Plug-in
dc.description.degree	Master's thesis
dc.description.degree	MSc
dc.format.extent	204 pages
dc.format.mimetype	application/pdf
dc.identifier.other	http://hdl.handle.net/10962/d1003720
dc.identifier.uri	https://researchrepository.ru.ac.za/handle/123456789/7450
dc.language	English
dc.publisher	Rhodes University, Faculty of Pharmacy, Pharmacy
dc.rights	Daya, Santylal
dc.subject	Steroid hormones
dc.subject	Pineal gland
dc.subject	Testosterone
dc.subject	Progesterone
dc.title	The influence of sex steroids on pineal enzymes
dc.type	Academic thesis

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