Studies on the metabolism of SKF 525 A

dc.contributor.advisor	Wilson, BJ
dc.contributor.author	Barber, Peter John
dc.date.accessioned	2026-03-04T14:38:22Z
dc.date.issued	1978,2013-10-14
dc.description.abstract	Spectrophotometric studies have been carried out to determine the pH dependence of binding of SKF 525 A, Brietal sodium and carbon monoxide to cytochrome P-450. The optimal pH for metabolic conversion of SKF 525 A has been investigated and this agent and its major metabolite, SKF 8742 A, have been metabolised in vitro by swine and rat hepatic microsomes. A suitable gas liquid chromatography assay has been developed and used to analyse metabolic production. The effects of carbon monoxide, dithiothreitol, n-octylamine and of induction of cytochrome P-450 by phenobarbital on metabolism of SKF 525 A and SKF 8742 A have been investigated. Attempts have been made to synthesise SKF 525 AN-oxide.,KMBT_363,Adobe Acrobat 9.54 Paper Capture Plug-in
dc.description.degree	Master's thesis
dc.description.degree	MSc
dc.format.extent	121 pages
dc.format.mimetype	application/pdf
dc.identifier.other	http://hdl.handle.net/10962/d1007591
dc.identifier.uri	https://researchrepository.ru.ac.za/handle/123456789/7473
dc.language	English
dc.publisher	Rhodes University, Faculty of Pharmacy, Pharmacy
dc.rights	Barber, Peter John
dc.subject	Drugs -- Metabolism
dc.subject	Cytochrome P-450
dc.title	Studies on the metabolism of SKF 525 A
dc.type	Academic thesis

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