The effects of Schiff Base Vanadium Complexes on glucose metabolism and their cytotoxicity in skeletal (C2C12) and hepatic (HEPG2) cells

Abstract

Diabetes mellitus (DM) is a leading cause of global mortality, as recognized by the World Health Organization. Current treatments face limitations in cost, efficacy, and safety, underscoring the need for alternative therapeutic options. Vanadium compounds have emerged as promising insulin mimetics, but their clinical application is hindered by toxicity concerns and side effects such as diarrhoea. This study investigates novel vanadium complexes synthesized through complexation with Schiff base ligands, aiming to enhance their efficacy while minimizing cytotoxicity.