The effects of Schiff Base Vanadium Complexes on glucose metabolism and their cytotoxicity in skeletal (C2C12) and hepatic (HEPG2) cells

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dc.contributor.advisorSibiya, Ntethelelo
dc.contributor.advisorKhanye, Setshaba
dc.contributor.advisorMakoni, Pedzisai
dc.contributor.authorChiwundura, Munyaradzi
dc.copyrightDate2025
dc.date.accessioned2026-03-18T13:30:29Z
dc.dateIssued2025-10-10
dc.description.abstractDiabetes mellitus (DM) is a leading cause of global mortality, as recognized by the World Health Organization. Current treatments face limitations in cost, efficacy, and safety, underscoring the need for alternative therapeutic options. Vanadium compounds have emerged as promising insulin mimetics, but their clinical application is hindered by toxicity concerns and side effects such as diarrhoea. This study investigates novel vanadium complexes synthesized through complexation with Schiff base ligands, aiming to enhance their efficacy while minimizing cytotoxicity.
dc.description.degreeMaster of Science
dc.description.degreeMaster's theses
dc.description.degreelevelMaster's
dc.digitalOriginborn digital
dc.disciplinePharmacology
dc.extent1 online resource (164 pages)
dc.formpdf
dc.form.carrieronline resource
dc.form.mediacomputer
dc.identifier.otherSibiya, Ntethelelo (https://orcid.org/0000-0001-5894-8935) [Rhodes University]
dc.identifier.otherKhanye, Setshaba (https://orcid.org/0000-0003-0725-5738) [Rhodes University]
dc.identifier.otherMakoni, Pedzisai (https://orcid.org/0000-0002-8475-447X) [Sefako Makgatho Health Sciences University]
dc.identifier.urihttps://researchrepository.ru.ac.za/handle/123456789/9960
dc.internetMediaTypeapplication/pdf
dc.language.isoeng
dc.language.isoEnglish
dc.note.thesisThesis (MSc) -- Faculty of Pharmacy, Pharmacy, 2025
dc.placeTerm.codesa
dc.placeTerm.textSouth Africa
dc.publisherRhodes University
dc.publisherFaculty of Pharmacy, Pharmacy
dc.rightsChiwundura, Munyaradzi
dc.rightsUse of this resource is governed by the terms and conditions of the Creative Commons "Attribution-NonCommercial-ShareAlike" License (http://creativecommons.org/licenses/by-nc-sa/2.0/)
dc.subject.ddcVanadium (http://id.loc.gov/authorities/subjects/sh85142005)
dc.subject.ddcDiabetes (http://id.loc.gov/authorities/subjects/sh85037456)
dc.subject.ddcInsulin (http://id.loc.gov/authorities/subjects/sh85066794)
dc.subject.ddcSchiff bases (http://id.loc.gov/authorities/subjects/sh85118118)
dc.titleThe effects of Schiff Base Vanadium Complexes on glucose metabolism and their cytotoxicity in skeletal (C2C12) and hepatic (HEPG2) cells
dc.typeAcademic theses
dc.typeOfResourcetext

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